In Vivo Pharmacokinetic studies – Rodent and Non Rodent

The in vivo Pharmacokinetic studies are critical for ensuring that the drug candidates have appropriate pharmacokinetic properties which can be evaluated in preclinical pharmacology and safety studies. The studies provide essential information which can help in determining human equivalent doses, no effect levels and PK/PD drivers. At VIMTA, we conduct routine PK studies using various routes of administration such as oral, sublingual, intravenous infusion, bolus, intragastric, intramuscular, subcutaneous and epicutaneous, transdermal, intravesical, intraperitoneal, intranasal, intra-tracheal and intra-dermal.

We also conduct

  • Bioavailability studiesin Mouse, Rat, Rabbit, Guinea pig and Dog by various routes of administration compared with IV infusion or bolus
  • Tissue discrete and uptake studies in Mouse and Rat
  • Optimization of suitable formulation and cassette dosing for discovery projects
  • Long term studies and capabilities for conducting ten studies at a time

Ocular Bio-distribution

  • Proficient in performing ocular tissue pharmacokinetics in Rabbits by following routes of administration
  • Topical
  • Sub-conjunctival
  • Intravitreal
  • Intrastromal
  • Expert in homogenation using small weight or volumes by suitable instruments 

Dermal Absorption

  • Competent in conducting occlusion, semi-occlusion, non- occlusion dermal absorption studies in Rodents and non-Rodents
  • Route of administration
  • Topical per square centimeter
  • Intradermal

Mass Balance for Non-Radiolabel Compounds

  • In Rodents and Non-Rodents by collecting of urine, faeces, bile, tissues or any other organs and cage-wash


Biliary Excretion

  • By cannulating bile duct in rat
  • Estimation of percentage excretion of parent and / or metabolite via bile


  • Jugular Vein Cannulation
  • Carotid Vein Cannulation
  • Bile Duct Cannulation
  • Femoral vein with extension to inferior vena cava
  • Portal vein cannulation