Gaining critical insight into the structure, function and stability of the complex molecules is a cornerstone in the development of peptide and protein-based drug. The data supports in ensuring the product maintains quality, efficacy and safety.

Comprehensive biophysical data is essential for regulatory submissions. The data obtained plays a vital role in quality control, drug optimization, understanding biological mechanism and in risk mitigation.

At VIMTA, we offer comprehensive biophysical characterization services for peptides and proteins to support drug development and research. Our state-of-the-art instrumentation and expert team provide reliable data for a deep understanding of the biomolecules.

Our instrumentations and techniques include:

Circular Dichroism (CD) spectroscopy is employed to determine the secondary structure of proteins and peptides, providing insights into conformational changes and stability.

Fluorescence Spectroscopy Fluorescent properties of amino acid residues enable studies on protein folding, interactions, and dynamics through fluorescence spectroscopy.

Size Exclusion Chromatography coupled with Multi-Angle Light Scattering (SEC-MALS) Precise determination of molecular weight and oligomeric state of proteins is achieved using SEC-MALS.

Sedimentation Velocity Analytical Ultracentrifugation (SV AUC) SV AUC offers detailed information about the size, shape, and interactions of proteins and protein complexes.

Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR FTIR) ATR FTIR provides structural information about proteins and peptides, including secondary structure and conformational changes.

Mass Spectrometry Analysis of Peptides and Proteins Our mass spectrometry expertise extends to various applications, including protein identification, quantification, post-translational modification analysis, and peptide mapping.

Impurity Profiling

Our biophysical techniques, such as SEC-MALS and mass spectrometry, can be employed to identify and quantify impurities, including variants, aggregates, and degradation products.

By combining these techniques with our in-depth knowledge, we provide relevant insights into the structure, function, and behaviour of the peptides and proteins.